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  Rationale Skincare

enriched hydration

PATIENT BENEFITS

• Maximum skin hydration from Intercellular Lipids (ILs) and Natural Moisturising Factors (NMFs) – the skin’s own moisturising systems.
• Helps restores suppleness and softness with phytoestrogens
• B-group vitamins (B3 & B5) assist with barrier function and reduce photo-induced sensitivity. Vitamin B also enhances the skin’s immune responses.
• Anti-oxidant vitamins A, C & E help reduce sensitivity, and protect from photo-damage.


NEED TO KNOW

• Dry skin is caused by a depletion of ILs and NMFs in the epidermis. Enriched Hydration works to replenish these components, fortifying the skin’s protective barrier.
• Dry skin is almost always sensitive. This is due to depletion of ILs and NMFs which normally protect the skin from irritants. When skin is deficient in these components, environmental irritants can more readily penetrate the epidermis and create sensitivity.


PRODUCT USAGE

• Enriched Hydration may be applied liberally at any time of day.
• A second layer of Enriched Hydration can be applied around the eye area to reduce dryness and sensitivity.


STUDIES AND FURTHER READING

Intercellular Lipids
According to research, topical physiological lipids such as
ceramides and cholesterol can restore biochemical balance in
barrier-impaired skin. Nonphysiological lipids such as lanolin
assist with barrier function without long-term correction. 1

Antioxidants
In vivo studies show topical anti-oxidants afford considerable
protection against UVA-induced damage. Studies also show
reduction in reactive oxygen species (ROS) with topical
antioxidant use. 2


INGREDIENTS:

Water (S), Lanolin [Medilan] 10% (IL), Caprylic/Capric Triglyceride (IL), Glyceryl Stearate (and) PEG-100 Stearate (E), Glycerin (NMF), PEG-40 Stearate (E), Cyclomethicone (M), Water (and) Pentylene Glycol (and) Glycerin (and) Sodium Lactate (and) Lactic Acid (and) Serine (and) Urea (and) Sorbitol (and) Sodium Chloride (and) Allantoin (NMF), Panthenol (B), Niacinamide (B), Cetearyl Alcohol (E), Sweet Orange Oil (M), Phenyl Trimethicone (M), Dimethicone (M), Sodium PCA (NMF), Carbomer (T), Lecithin (and) Polysorbate 20 (and) Sorbitan Laurate (and) Propylene Glycol Stearate (and) Propylene Glycol Laurate (E), Tocopherol Acetate (A), Retinyl Palmitate (A), Cyclomethicone (and) Soybean Oil (and) Phospholipids (and) Oleic Acid (and) Linoleic Acid (and) Tocopheryl Acetate (and) Linolenic Acid (and) Ceramides III (and) Cholesterol (and) Phytosphingosine (IL), Ethoxydiglycol (and) Propylene Glycol (and) Butylene Glycol (and) Panax Ginseng Root Extract (and) Glucose (PE), Ascorbyl Palmitate (A), Bisabolol (PE), Cholesterol (IL), Propylparaben (P), Hydroxyethylcellulose (T), Methylparaben (P), Allantoin (M), Imidazolidinyl Urea (P), Sodium Hydroxide (T).

Codebreaker: S=solvent, IL=intercellular lipid, E=emulsifier, NMF=natural moisturising factor, M=moisturiser, B=B-group vitamins, T=thickener, A=antioxidant, PE=phytoestrogen, P=preservative


EXPLANATIONS

Intercellular Lipids
lanolin
ceramides
cholesterol
triglycerides

Augment ILs in intercellular spaces of stratum corneum. Facilitate barrier lipid repair. Natural Moisturising Factors
glycerin sodium lactate lactic acid urea serine

Supplement NMFs in stratum corneum to enhance moisture-binding capacity in upper epidermis. B-group vitamins niacinamide (Vit. B3) 2% panthenol (Vit. B5) 2%

Help reduce sensitivity by protecting immune function and fortifying barrier function Antioxidants retinyl palmitate (Vit. A ester) ascorbyl pamitate (Vit. C ester) tocopherol acetate (Vit. E ester)

Act as exogenous free radical scavengers to militate against formation of reactive oxygen species and other free radicals.

Phytoestrogens
bisabolol 0.25%
panax ginseng 0.1%

Help smooth and soften dry skin. Promotes suppleness and elasticity.


STUDIES AND FURTHER READING

INTERCELLULAR LIPIDS

Topical physiological lipids such as ceramides and cholesterol can help restore biochemical balance in barrier-impaired skin. Nonphysiological lipids such as lanolin assist with barrier function without long-term correction.1


B GROUP VITAMINS

Recent research by Bissett et.al has revealed that Niacinamide and Panthenol can play an important role in preserving the skin’s immune surveillance responses and reducing sensitivity by helping to strengthen barrier function.2


MEDILAN

Purified medical grade lanolin (Medilan) is a superior non-physiological lipid for use in wound healing when compared to petrolatum and other occlusive agents3


ANTIOXIDANTS

In vivo studies show topical anti-oxidants afford considerable protection against UVA-induced damage. Studies also show reduction in reactive oxygen species (ROS) with topical antioxidant use.4


PHYTOESTROGENS

Studies show phytoestrogens help improve barrier function. They may also be implicated in the prevention of ageing-related lipid peroxidation. Evidence also suggests that they mimic the skin softening and hydrating effects of endogenous estrogens.5

1. Elias, Peter M. “Physiological Lipids for Barrier Repair in Dermatology.” Cosmeceuticals. Ed. Zoe Draelos. Philadelphia: Elsevier, 2005. p. 63-70.

2. Bissett, D. et al. “Cosmeceutical Vitamins: Vitamin B.” Cosmeceuticals. Ed. Zoe Draelos. Philadelphia: Elsevier, 2005. p. 57-62.

3. Kligman, A. et al. “Clinical study to compare the effect of Medilan Ultra and petrolatum on the rate of wound healing in experimentally-induced blister wounds.” Croda Health Care UK, July 2004.

4. Thiele, J and Dreher, F. “Antioxidant Defense Systems in Skin.”. Cosmeceuticals and Active Cosmetics. Ed. Peter Elsner. Boca Raton: Taylor & Francis, 2005. p 37-88.

5. Bayerl, C. “Phytosterols.” Cosmeceuticals and Active Cosmetics. p. 279-292.

 

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