retinaldehyde serum
PATIENT BENEFITS
• Provides outstanding retinoid benefits with low irritancy profile.
• Smooths and clarifies skin tone and texture.
• Increases skin hydration.
• Assists repair following UV exposure and sun damage.
• Illuminates complexion and helps fade pigmentation.
NEED TO KNOW
• Use RAL as a non-irritating alternative to RA, where patients are intolerant of RA therapy or are non-compliant due to side-effects
• As with all retinoids, avoid use during pregnancy.
PRODUCT USAGE
Use nightly. Cleanse with Rationale Preparatory Cleanser.
Apply a few drops of Rationale Retinaldehyde Serum to face, neck, chest and backs of hands. Follow with Rationale Skin Refining Serum and Rationale Moisture+ or Enriched Hydration.
INGREDIENTS:
Water (S), Butylene Glycol (S), C12-15 Alkyl Benzoate (M), Phenoxyethanol (and) Methylparaben (and) Butylparaben (and) Propylparaben (and) Ethylparaben (P), Sodium Hyaluronate (M), Natto Gum (AO), Butylated Hydroxytolulene (AO), Retinaldehyde (A), PEG-40 Hydrogenated Castor Oil (M), Sodium Bisulfite (AO).
Codebreaker: S = Solvent, M = Moisturiser, P = Preservative,
AO = Anti-oxidant, A = Vitamin A.
RETINALDEHYDE
Vitamin A has been used in dermatology for many years in prescription and over-the-counter forms. It has the ability to repair signs of sun damage and premature ageing such as wrinkles, pigmentation and rough, dry skin. Most forms of vitamin A are irritating and can cause redness, peeling and sensitivity. Retinaldehyde is a non-irritating Vitamin A metabolite which displays all of the benefits of vitamin A therapy for the skin without causing undesirable side effects.
RECENT STUDIES
PHOTOAGEING
Clinical studies show significant reduction in the presentation of wrinkles and roughness using 0.05%+ retinaldehyde. Other studies show the benefits of retinaldehyde to be analogous to that of retinoic acid but without the irritant effects. Clinical effects include epidermal thickening and repair of UVA-induced collagen damage.
ACNE
• In vitro modeling and in in vivo trials suggest retinaldehyde shows significant (~99%) anti-bacterial activity against P. acnes.
• RAL reduces comedones in the mouse model by more than 50%
• 33% less erythema and no burning/pruritus compared to ROL or RA.
ROSACEA
Cultured human cell model studies indicate that retinaldehyde is effective in decreasing vascular endothelial growth factor (VEGF), an angiogenic factor implicated in angiogenesis-dependent skin disorders such as rosacea.
TOLERANCE
Retinaldehyde is shown to be very well tolerated at .05% concentrations over extended (<3 years) time frames.
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